Indomethacin (sodium)

• UNSPSC Description:

  Indomethacin (Indometacin) sodium is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium has anticancer activity and anti-infective activity. Indomethacin sodium can be used for cancer, inflammation and viral infection research.[1][2][3].

• Target Antigen:

  Antibiotic; Bacterial; COX; Influenza Virus

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Immunology/Inflammation

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/indomethacin-sodium.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O[Na])CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3

• Molecular Weight:

  379.77

• References & Citations:

  [1]Riendeau D, et, al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.|[2]Amici C, et, al. Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR. Cell Microbiol. 2015 Sep;17(9):1391-404.|[3]Eli Y, et, al. Comparative effects of indomethacin on cell proliferation and cell cycle progression in tumor cells grown in vitro and in vivo. Biochem Pharmacol. 2001 Mar 1;61(5):565-71.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  7681-54-1