ZL-Pin01

• Description :

  ZL-Pin01 is a high potent covalent Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC50 of 1.33 μM[1].

• UNSPSC :

  12352005

• Target :

  PIN1

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/zl-pin01.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C1CSC2(CCN(C(CCl)=O)CC2)N1CC3=CC=CO3

• Molecular Formula :

  C14H17ClN2O3S

• Molecular Weight :

  328.81

• References & Citations :

  [1]Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1) . J Med Chem. 2022;65 (3) :2174-2190.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1047464-92-5]