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GPP78

CAT: 0804-HY-14374Size: 5 mg (11.38 mM x 1 mL in Methanol)Dry Ice: NoHazardous: No
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CAT#:0804-HY-14374Size:5 mg (11.38 mM x 1 mL in Methanol)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects[1][2].
CAS Number
1202580-59-3
Product Name Alternative
CAY10618
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; NAMPT
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gpp78.html
Concentration
11.38 mM * 1 mL in Methanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(CCCCCCCN1N=NC(C2=CN=CC=C2)=C1)NC3=CC=CC=C3C4=CC=CC=C4
Molecular Formula
C27H29N5O
Molecular Weight
439.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53 (2) :616-23.|[2]Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012 Apr 10;9:66.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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C04551-1mgGPP78

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