GPP78

CAT: 0931-T15412-03Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T15412-03Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1202580-59-3

Target

Autophagy, NAMPT

Related Pathways

Metabolism, Autophagy

Bioactivity

GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion) . GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy) . GPP78 has anti-cancer and anti-inflammatory effects.

Smiles

N(C(CCCCCCCN1C=C(N=N1)C=2C=CC=NC2)=O)C3=C(C=CC=C3)C4=CC=CC=C4

Molecular Formula

C27H29N5O

Molecular Weight

439.55

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide

GPP78 is a biphenyl that is substituted by a {8-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]octanoyl}amino group at position 2. It has a role as an autophagy inducer and an EC 2.4.2.12 (nicotinamide phosphoribosyltransferase) inhibitor. It is a secondary carboxamide, a member of biphenyls, a member of pyridines and a member of triazoles.

CAS Number	1202580-59-3
PubChem CID	44819697
IUPAC Name	N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide
Molecular Formula	C27H29N5O
Molecular Weight	439.6
XLogP	4.8
Topological Polar Surface Area	72.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	11
Heavy Atom Count	33
Formal Charge	0
Complexity	567

SMILES

C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)CCCCCCCN3C=C(N=N3)C4=CN=CC=C4

InChI

InChI=1S/C27H29N5O/c33-27(29-25-16-9-8-15-24(25)22-12-5-4-6-13-22)17-7-2-1-3-10-19-32-21-26(30-31-32)23-14-11-18-28-20-23/h4-6,8-9,11-16,18,20-21H,1-3,7,10,17,19H2,(H,29,33)

InChIKey

SJOLTIOPWDLDEB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1202580-59-3

CID: 44819697

Formula: C27H29N5O

MW: 439.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	439.6
XLogP3	4.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	11
Exact Mass	439.23721057
Monoisotopic Mass	439.23721057
Topological Polar Surface Area	72.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	567
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
C04551-1mg	GPP78

GPP78

Chemical Information

Alternative Products

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