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GPP78

CAT: 0013-GTR19203825-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203825-04Size:10 mg
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Description
GPP78 is a potent and selective Nampt inhibitor with an IC50 of 3.0 nM for NAD depletion. It demonstrates cytotoxicity in neuroblastoma SH-SY5Y cells via autophagy induction (IC50: 3.8 nM), supporting its investigation in cancer and inflammation research both in vitro and in vivo.
CAS Number
1202580-59-3
Field of Research
Cell Biology, Metabolism Research
Smiles
N (C (CCCCCCCN1C=C (N=N1) C=2C=CC=NC2) =O) C3=C (C=CC=C3) C4=CC=CC=C4
Molecular Formula
C27H29N5O
Molecular Weight
439.55
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide

GPP78 is a biphenyl that is substituted by a {8-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]octanoyl}amino group at position 2. It has a role as an autophagy inducer and an EC 2.4.2.12 (nicotinamide phosphoribosyltransferase) inhibitor. It is a secondary carboxamide, a member of biphenyls, a member of pyridines and a member of triazoles.

CAS Number1202580-59-3
PubChem CID44819697
IUPAC NameN-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide
Molecular FormulaC27H29N5O
Molecular Weight439.6
XLogP4.8
Topological Polar Surface Area72.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Heavy Atom Count33
Formal Charge0
Complexity567
SMILES
C1=CC=C(C=C1)C2=CC=CC=C2NC(=O)CCCCCCCN3C=C(N=N3)C4=CN=CC=C4
InChI
InChI=1S/C27H29N5O/c33-27(29-25-16-9-8-15-24(25)22-12-5-4-6-13-22)17-7-2-1-3-10-19-32-21-26(30-31-32)23-14-11-18-28-20-23/h4-6,8-9,11-16,18,20-21H,1-3,7,10,17,19H2,(H,29,33)
InChIKey
SJOLTIOPWDLDEB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-phenylphenyl)-8-(4-pyridin-3-yltriazol-1-yl)octanamide
CAS: 1202580-59-3
CID: 44819697
Formula: C27H29N5O
MW: 439.6
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight439.6
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count11
Exact Mass439.23721057
Monoisotopic Mass439.23721057
Topological Polar Surface Area72.7 Ų
Heavy Atom Count33
Formal Charge0
Complexity567
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C04551-1mgGPP78

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