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PI3Kδ-IN-11

CAT: 0804-HY-143472Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143472Size:1 Each
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Description
PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies[1].
CAS Number
2413257-51-7
UNSPSC
12352005
Target
Akt; Apoptosis; PI3K
Type
Reference compound
Related Pathways
Apoptosis; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-11.html
Solubility
10 mM in DMSO
Smiles
C=CC(NC1=CC(NC2=C3C=C(C4=CC5=CC=CC=C5N=C4)C=CC3=NC=N2)=CC=C1C)=O
Molecular Formula
C27H21N5O
Molecular Weight
431.49
References & Citations
[1]Teng Y, Li X, Ren S, et al. Discovery of novel quinazoline derivatives as potent PI3Kδ inhibitors with high selectivity. Eur J Med Chem. 2020;208:112865.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kδ

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