Hit 1

CAT: 0804-HY-143401Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-143401Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Hit 1 is an activator of ansulin degrading enzyme (IDE), with an EC50 of 5.5 μM. Hit 1 can decrease glucose-stimulating insulin secretion[1].

CAS Number

2785377-42-4

UNSPSC

12352005

Target

Proteolytic Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hit-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCCN1C=CN=C1)CCCC2=CN(C3=CC=CC=C23)S(=O)(C4=CC=CS4)=O

Molecular Formula

C22H24N4O3S2

Molecular Weight

456.58

References & Citations

[1]Kraupner N, et, al. Identification of indole-based activators of insulin degrading enzyme. Eur J Med Chem. 2022 Jan 15;228:113982.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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