(S) -V-0219

• Target:

  Glucagon Receptor|||Others

• Related Pathways:

  GPCR/G Protein|||Others

• Bioactivity:

  (S) -V-0219, an enantiomer of V-0219, is an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R) . It activates calcium fluxes in HEK cells stably expressing hGLP-1R, demonstrating its oral activity. Additionally, (S) -V-0219 ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice [1].

• Smiles:

  C1C[C@H] (CN (C1) CC2=NC (=NO2) C3=CC=C (C=C3) C (F) (F) F) CN4CCOCC4

• Molecular Formula:

  C20H25F3N4O2

• Molecular Weight:

  410.43

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C