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(S) -V-0219

CAT: 0931-T73081-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T73081-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Glucagon Receptor, Others
Related Pathways
GPCR/G Protein, Others
Bioactivity
(S) -V-0219, an enantiomer of V-0219, is an orally active positive allosteric modulator (PAM) of the GLP-1 Receptor (GLP-1R) . It activates calcium fluxes in HEK cells stably expressing hGLP-1R, demonstrating its oral activity. Additionally, (S) -V-0219 ameliorates high glucose levels in mice and inhibits feeding behavior in fasted mice [1].
Smiles
C1C[C@H](CN(C1)CC2=NC(=NO2)C3=CC=C(C=C3)C(F)(F)F)CN4CCOCC4
Molecular Formula
C20H25F3N4O2
Molecular Weight
410.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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