Products for Research Use Only
RegisterLogin

Cimetidine-d3

CAT: 0804-HY-14289SSize: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14289SSize:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Cimetidine-d3 is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
CAS Number
1185237-29-9
Product Name Alternative
SKF-92334-d3
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Histamine Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Cancer; Endocrinology
Solubility
10 mM in DMSO
Smiles
N#CN/C(NC([2H])([2H])[2H])=N/CCSCC1=C(N=CN1)C
Molecular Formula
C10H13D3N6S
Molecular Weight
255.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93 (13) :6802-7.|[3]Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70 (2) : p. 450-3.|[4]Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94 (5) : p. 585-92.|[5]Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54 (1) : p. 74-83.|[6]Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376.|[7]Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
H2 Receptor

Related Products

CatalogName
HY-14289-01Cimetidine
HY-14289R-01Cimetidine (Standard)
HY-136338-01Cimetidine sulfoxide
HY-14289ACimetidine (hydrochloride)
HY-136338RCimetidine sulfoxide (Standard)
HY-14289ARCimetidine (hydrochloride) (Standard)
HY-15398S3-01Vitamin D3-d3
HY-132348S1Granisetron-d3 (1-methyl-d3)
HY-150954SL-Methionine-d3 (S-methyl-d3) Methyl-d3-sulfonium Chloride
HY-W758392(±) -Ipratropium-d3 Bromide (N-methyl-d3)

Alternative Products

CatalogName
RM-C132036-01Cimetidine-D3
AR-C07610-01Cimetidine EP Impurity E-d3 (Cimetidine Sulphoxide-d3)
163099Cimetidine Sulfoxide-d3
B1557-5.1Cimetidine

Popular Products