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Cimetidine

CAT: 0804-HY-14289-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14289-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
CAS Number
51481-61-9
Product Name Alternative
SKF-92334
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Histamine Receptor
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Cimetidine.html
Purity
98.0
Solubility
DMSO : 60 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)
Smiles
CC1=C(CSCC/N=C(NC)/NC#N)NC=N1
Molecular Formula
C10H16N6S
Molecular Weight
252.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Takahashi, H.K., et al., Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol, 2006. 70 (2) : p. 450-3.|[2]Sprowl, J.A., et al., Conjunctive therapy of cisplatin with the OCT2 inhibitor cimetidine: influence on antitumor efficacy and systemic clearance. Clin Pharmacol Ther, 2013. 94 (5) : p. 585-92.|[3]Zheng, Y., et al., Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol, 2013. 54 (1) : p. 74-83.|[4]Fukuda, M., K. Kusama, and H. Sakashita, Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression. BMC Cancer, 2008. 8: p. 376.|[5]Longhini, R., et al., Cimetidine Reduces the Alveolar Bone Loss in Induced Periodontitis in Rat Molars. J Periodontol, 2013.|[6]M J Smit, et al. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proc Natl Acad Sci U S A. 1996 Jun 25;93 (13) :6802-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H2 Receptor; Histamine Receptor

Alternative Products

CatalogName
B1557-5.1Cimetidine

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