M-MoDE-A (2)

M-MoDE-A (2)

• CAS Number: 2378837-56-8
• UNSPSC Description: M-MoDE-A (2) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).
• Target Antigen: LYTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/m-mode-a-2.html
• Solubility: 10 mM in DMSO
• Smiles: CC(N[C@H]([C@H]([C@H]([C@H](O1)CO)O)O)[C@@H]1OCCOCCOCCNC(CCOCC(COCCC(NCCOCCOCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)NC(C)=O)=O)(COCCC(NCCOCCOCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(C)=O)=O)NC(CNC(CCCOC4=CC5=C(C=C4)N=C(C6=CN(C7=CC(F)=C(C=C7)O)N=N6)C=C5)=O)=O)=O)=O
• Molecular Weight: 1787.84
• References & Citations: [1]Caianiello DF, et al. Bifunctional small molecules that mediate the degradation of extracellular proteins. Nat Chem Biol. 2021 Sep;17(9):947-953.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported