D-MoDE-A (1)

• Description :

  D-MoDE-A (1) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR) .

• UNSPSC :

  12352005

• Target :

  LYTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/d-mode-a-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=[N+]([O-])C(C=C(C=C1)[N+]([O-])=O)=C1NCCOCCOCCOCC(NCC(NC(COCCC(NCCOCCOCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)NC(C)=O)=O)(COCCC(NCCOCCOCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(C)=O)=O)COCCC(NCCOCCOCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O)=O)=O

• Molecular Formula :

  C71H121N11O39

• Molecular Weight :

  1752.77

• References & Citations :

  [1]Caianiello DF, et al. Bifunctional small molecules that mediate the degradation of extracellular proteins. Nat Chem Biol. 2021 Sep;17 (9) :947-953.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2378837-67-1]