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D-MoDE-A (1)

CAT: 0804-HY-142881Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142881Size:1 Each
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Description
D-MoDE-A (1) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR) .
CAS Number
2378837-67-1
UNSPSC
12352005
Target
LYTACs
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/d-mode-a-1.html
Solubility
10 mM in DMSO
Smiles
O=[N+]([O-])C(C=C(C=C1)[N+]([O-])=O)=C1NCCOCCOCCOCC(NCC(NC(COCCC(NCCOCCOCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)NC(C)=O)=O)(COCCC(NCCOCCOCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(C)=O)=O)COCCC(NCCOCCOCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O)=O)=O
Molecular Formula
C71H121N11O39
Molecular Weight
1752.77
References & Citations
[1]Caianiello DF, et al. Bifunctional small molecules that mediate the degradation of extracellular proteins. Nat Chem Biol. 2021 Sep;17 (9) :947-953.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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