D-MoDE-A (1)

D-MoDE-A (1)

• CAS Number: 2378837-67-1
• UNSPSC Description: D-MoDE-A (1) is a bifunctional small molecule that mediates the degradation of extracellular proteins through the asialoglycoprotein receptor (ASGPR).
• Target Antigen: LYTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/d-mode-a-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=[N+]([O-])C(C=C(C=C1)[N+]([O-])=O)=C1NCCOCCOCCOCC(NCC(NC(COCCC(NCCOCCOCCO[C@H]2[C@@H]([C@H]([C@H]([C@H](O2)CO)O)O)NC(C)=O)=O)(COCCC(NCCOCCOCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(C)=O)=O)COCCC(NCCOCCOCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O)=O)=O
• Molecular Weight: 1752.77
• References & Citations: [1]Caianiello DF, et al. Bifunctional small molecules that mediate the degradation of extracellular proteins. Nat Chem Biol. 2021 Sep;17(9):947-953.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported