TRPV1 antagonist 7

TRPV1 antagonist 7

• UNSPSC Description: TRPV1 antagonist 7 (Compound 36) is a selective TRPV1 antagonist that effectively blocks capsaicin activation (IC50=2.31 nM). TRPV1 antagonist 7 can be used in analgesic research[1].
• Target Antigen: TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/trpv1-antagonist-7.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=CC(C2=C(CNC(NC3=CC=CC(N4)=C3OCC4=O)=O)SC(C(C)(C)C)=N2)=C1
• Molecular Weight: 470.97
• References & Citations: [1]Huang G, et al. Discovery of N-(1,4-Benzoxazin-3-one) urea analogs as Mode-Selective TRPV1 antagonists. Bioorg Med Chem Lett. 2024 Apr 6:129735.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported