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Milrinone-d3

CAT: 0804-HY-14252SSize: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-14252SSize:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Milrinone-d3 is deuterium labeled Milrinone. Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.
CAS Number
2749393-50-6
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
N#CC1=CC(C2=CC=NC=C2)=C(C([2H])([2H])[2H])NC1=O
Molecular Formula
C12H6D3N3O
Molecular Weight
214.24
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hentschel T, et al. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology. 2007 Jan;106 (1) :124-31.|[3]Kishi T, et al. Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ. Clin Exp Pharmacol Physiol. 2001 Sep;28 (9) :737-42.|[4]Santhosh KT, et al. Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes. Br J Pharmacol. 2011 Jul;163 (6) :1223-36.|[5]Taylor MS, et al. Effect of milrinone on small mesenteric artery vasoconstriction: role of K (+) channels. Am J Physiol. 1999 Jul;277 (1 Pt 1) :G69-78.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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