Milrinone-d3

• Description :

  Milrinone-d3 is deuterium labeled Milrinone. Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.

• UNSPSC :

  12352005

• Target :

  Isotope-Labeled Compounds; Phosphodiesterase (PDE)

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CC1=CC(C2=CC=NC=C2)=C(C([2H])([2H])[2H])NC1=O

• Molecular Formula :

  C12H6D3N3O

• Molecular Weight :

  214.24

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hentschel T, et al. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology. 2007 Jan;106 (1) :124-31.|[3]Kishi T, et al. Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ. Clin Exp Pharmacol Physiol. 2001 Sep;28 (9) :737-42.|[4]Santhosh KT, et al. Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes. Br J Pharmacol. 2011 Jul;163 (6) :1223-36.|[5]Taylor MS, et al. Effect of milrinone on small mesenteric artery vasoconstriction: role of K (+) channels. Am J Physiol. 1999 Jul;277 (1 Pt 1) :G69-78.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [2749393-50-6]