Milrinone

• UNSPSC Description:

  Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator.

• Target Antigen:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Milrinone.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC(N1)=C(C2=CC=NC=C2)C=C(C#N)C1=O

• Molecular Weight:

  211.22

• References & Citations:

  [1]Santhosh KT, et al. Milrinone attenuates thromboxane receptor-mediated hyperresponsiveness in hypoxic pulmonary arterial myocytes. Br J Pharmacol. 2011 Jul;163(6):1223-36.|[2]Hentschel T, et al. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology. 2007 Jan;106(1):124-31.|[3]Kishi T, et al. Effects of milrinone on left ventricular end-systolic pressure-volume relationship of rat hearts in situ. Clin Exp Pharmacol Physiol. 2001 Sep;28(9):737-42.|[4]Taylor MS, et al. Effect of milrinone on small mesenteric artery vasoconstriction: role of K(+) channels. Am J Physiol. 1999 Jul;277(1 Pt 1):G69-78.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  78415-72-2