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Letrozole-d4

CAT: 0804-HY-14248SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14248SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Letrozole-d4 (CGS 20267-d4) is the deuterium labeled Letrozole. Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].
CAS Number
1133712-96-5
UNSPSC
12352005
Hazard Statement
H351, H360, H373
Target
Autophagy; Cytochrome P450; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.23
Solubility
10 mM in DMSO|DMF : ≥ 16mg/mL|DMSO : ≥ 16mg/mL
Smiles
C(C1=C(C(=C(C#N)C(=C1[2H])[2H])[2H])[2H])(C2=CC=C(C#N)C=C2)N3C=NC=N3
Molecular Formula
C17H7D4N5
Molecular Weight
289.33
Precautions
H351, H360, H373
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bhatnagar AS, et, al. Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol. 1990 Dec 20;37 (6) :1021-7.|[3]Mitropoulou TN, et, al. Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int J Cancer. 2003 Mar 20;104 (2) :155-60.|[4]Schieweck K, et, al. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors. J Steroid Biochem Mol Biol. 1993 Mar;44 (4-6) :633-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Aromatase/CYP19A1

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