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Con B-1

CAT: 0804-HY-142287Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-142287Size:1 Each
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Description
ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells[1].
CAS Number
2415537-51-6
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/con-b-1.html
Solubility
10 mM in DMSO
Smiles
C=CC(NCCOCCNC(CCN1CCC(CC1)C2=CC(OC(C)C)=C(C=C2C)NC3=NC(NC4=C(C=CC=C4)S(=O)(C(C)C)=O)=C(C=N3)Cl)=O)=O
Molecular Formula
C38H52ClN7O6S
Molecular Weight
770.38
References & Citations
[1]Yan G, et al. Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design. J Med Chem. 2021 Feb 11;64 (3) :1558-1569.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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