Con B-1

• UNSPSC Description:

  ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells[1].

• Target Antigen:

  Anaplastic lymphoma kinase (ALK)

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/con-b-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=CC(NCCOCCNC(CCN1CCC(CC1)C2=CC(OC(C)C)=C(C=C2C)NC3=NC(NC4=C(C=CC=C4)S(=O)(C(C)C)=O)=C(C=N3)Cl)=O)=O

• Molecular Weight:

  770.38

• References & Citations:

  [1]Yan G, et al. Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design. J Med Chem. 2021 Feb 11;64(3):1558-1569.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 1

• CAS Number:

  2415537-51-6