Diazo Biotin-PEG3-DBCO

• UNSPSC Description:

  Diazo Biotin-PEG3-DBCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Diazo Biotin-PEG3-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  ADC Linker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/diazo-biotin-peg3-dbco.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]1(N2)CS[C@H]([C@@](NC2=O)1[H])CCCCC(NCCOCCOCCOCCNC(C3=CC=C(C=C3)/N=N/C4=CC(CCNC(CCC(N5CC6=CC=CC=C6C#CC7=CC=CC=C57)=O)=O)=CC=C4O)=O)=O

• Molecular Weight:

  973.15

• References & Citations:

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported