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LeuRS-IN-1

CAT: 0804-HY-139987Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139987Size:1 Each
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Description
LeuRS-IN-1 is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 has IC50 and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively[1]. LeuRS-IN-1 inhibits human cytoplasmic LeuRS (IC50=38.8 μM), and HepG2 protein synthesis (EC50=19.6 μM) [2].
CAS Number
1364914-72-6
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/leurs-in-1.html
Solubility
10 mM in DMSO
Smiles
CCOC1=C2C([C@H](OB2O)CN)=C(C=C1)Cl
Molecular Formula
C10H13BClNO3
Molecular Weight
241.48
References & Citations
Antimicrob Agents Chemother
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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