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LeuRS-IN-2

CAT: 0804-HY-159103Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159103Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC50 value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota[1].
UNSPSC
12352005
Target
Aminoacyl-tRNA Synthetase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/leurs-in-2.html
Smiles
CN(CCCOC1=CC=C(Br)C2=C1B(O)O[C@@H]2CN)CC3=CC=CC=C3
Molecular Formula
C19H24BBrN2O3
Molecular Weight
419.12
References & Citations
[1]Hoffmann G, et al. Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host[J]. Sci Adv. 2024 Jul 12;10 (28) :eado1453.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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