MK-4688

• Description :

  MK-4688 is an efficient inhibitor of the HDM2-p53 protein-protein interaction.

• CAS Number :

  [1616428-79-5]

• UNSPSC :

  12352005

• Target :

  MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mk-4688.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@H](CC1)CC[C@H]1CN(C(N2CCO[C@H]3[C@H]2CCC3)=N4)C5=C4C=C(C(N6)=NOC6=O)N=C5C7=CC(Cl)=CN=C7

• Molecular Formula :

  C28H32ClN7O3

• Molecular Weight :

  550.05

• References & Citations :

  [1]Reutershan MH, et al. Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64 (21) :16213-16241.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported