Antiviral agent 9

CAT: 0804-HY-139845Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-139845Size:1 Each
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Description
Antiviral agent 9 reaches a single-digit picomolar EC50 value (0.006 nM) against HIV-1 and nearly 300-fold higher selectivity index (SI) compared to tenofovir alafenamide fumarate (TAF) .
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antiviral-agent-9.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C(OC(C)C)=O)NP(OC1=CC=C(C[C@H](NC(OCC2=CC=CC=C2)=O)C(CC3CCCC3)=O)C=C1)(CO[C@H](C)CN4C=NC5=C(N)N=CN=C45)=O
Molecular Formula
C38H50N7O8P
Molecular Weight
763.82
References & Citations
[1]Kalčic F, et al. Discovery of Modified Amidate (ProTide) Prodrugs of Tenofovir with Enhanced Antiviral Properties. J Med Chem. 2021 Nov 25;64 (22) :16425-16449.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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