NI-Pano

• UNSPSC Description:

  NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor. NI-Pano (CH-03) is reduced in an O2-dependent manner to release panobinostat.

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ni-pano.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(N1)=C(CCNCC2=CC=C(/C=C/C(NOCC3=CN=C([N+]([O-])=O)N3C)=O)C=C2)C4=C1C=CC=C4

• Molecular Weight:

  488.54

• References & Citations:

  [1]Skwarska A, et al. Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor. Cell Chem Biol. 2021 Sep 16;28(9):1258-1270.e13.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2733559-66-3