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NI-42 (Standard)

CAT: 0804-HY-101121RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101121RSize:1 Each
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Description
NI-42 (Standard) is the analytical standard of NI-42. This product is intended for research and analytical applications. NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins[1].
CAS Number
1884640-99-6
Target
Epigenetic Reader Domain; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
O=S(C1=CC=C(C#N)C=C1)(NC2=CC=C(N(C)C(C(C)=C3)=O)C3=C2)=O
Molecular Formula
C18H15N3O3S
Molecular Weight
353.40
References & Citations
[1]Igoe N, et al. Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem. 2017 Jan 26;60 (2) :668-680.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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