MS83

• Description :

  MS83 is a proof-of-concept PROTAC by linking the KEAP1 ligand to a BRD4/3/2 binder.

• CAS Number :

  [2762181-19-9]

• UNSPSC :

  12352005

• Target :

  PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ms83.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S1(C2=CC=CC=C2O[C@H](C)CN1CC3=CC([C@@H](C4=CC(OCCNC(CNC(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)=O)=C(N(C)N=N9)C9=C4)CC(OCC)=O)=CC=C3C)=O

• Molecular Formula :

  C52H55ClN10O8S2

• Molecular Weight :

  1047.64

• References & Citations :

  [1]Wei J, et al. Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. J Am Chem Soc. 2021 Sep 22;143 (37) :15073-15083.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported