Products for Research Use Only
RegisterLogin

Telmisartan-d7

CAT: 0804-HY-13955S3Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13955S3Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Telmisartan-d7 (BIBR 277-d7) is a deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
CAS Number
1794754-60-1
Product Name Alternative
BIBR 277-d7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Angiotensin Receptor; Autophagy; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; GPCR/G Protein; Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.57
Solubility
10 mM in DMSO
Smiles
CCCC(N(C1=CC(C2=NC3=CC=CC=C3N2C([2H])([2H])[2H])=C4)CC5=C([2H])C([2H])=C(C6=C(C=CC=C6)C(O)=O)C([2H])=C5[2H])=NC1=C4C
Molecular Formula
C33H23D7N4O2
Molecular Weight
521.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Maillard MP, et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther. 2002 Sep;302 (3) :1089-95.|[3]Xuan H, et al. Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. J Vasc Surg. 2017 Apr 20. pii: S0741-5214 (17) 30100-3.|[4]Torika N, et al. Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice. Brain Behav Immun. 2017 Apr 3.|[5]Aswar U, et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr;69 (2) :358-364.|[6]Fujihara S, et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31;8 (5) :8536-8549.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-13955-01Telmisartan
HY-13955STelmisartan-d3
HY-13955S1Telmisartan-d4
HY-13955R-01Telmisartan (Standard)
HY-Z0129-01Telmisartan impurity 2
HY-13955S2-01Telmisartan-13C, d3
HY-137959-01Telmisartan acyl-β-D-glucuronide
HY-B0573S1-01Propranolol-d7 (ring-d7)
HY-W745140Hydroxyatenolol-d7
HY-W727525Donepezil-d7

Alternative Products

CatalogName
TRC-T017003-1MGTelmisartan-d7
S1738-100mgTelmisartan

Popular Products