Products for Research Use Only

Telmisartan (Standard)

CAT: 0804-HY-13955R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13955R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
CAS Number
144701-48-4
Product Name Alternative
BIBR 277 (Standard)
UNSPSC
12352005
Target
Angiotensin Receptor; Autophagy; Reference Standards
Type
Reference Standards
Related Pathways
Autophagy; GPCR/G Protein; Others
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/telmisartan-standard.html
Smiles
O=C(C1=CC=CC=C1C2=CC=C(CN3C4=CC(C5=NC6=CC=CC=C6N5C)=CC(C)=C4N=C3CCC)C=C2)O
Molecular Formula
C33H30N4O2
Molecular Weight
514.62
References & Citations
[1]Maillard MP, et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther. 2002 Sep;302 (3) :1089-95.|[2]Xuan H, et al. Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. J Vasc Surg. 2017 Apr 20. pii: S0741-5214 (17) 30100-3.|[3]Torika N, et al. Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice. Brain Behav Immun. 2017 Apr 3.|[4]Aswar U, et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr;69 (2) :358-364.|[5]Fujihara S, et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31;8 (5) :8536-8549.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Clinical Information
Launched

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