Thalidomide-5-NH-PEG1-NH2 (hydrochloride)

• UNSPSC Description:

  Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide (HY-14658)-based cereblon ligand that recruits CRBN proteins. Thalidomide-5-NH-PEG1-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032 (HY-123937).

• Target Antigen:

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-5-nh-peg1-nh2-hydrochloride.html

• Purity:

  98.87

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCN)C=C3C2=O)=O)=O.Cl

• Molecular Weight:

  396.83

• References & Citations:

  [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.  [Content Brief]

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Clinical Information:

  No Development Reported

• CAS Number:

  2863634-98-2