Deoxythymidine-5'-triphosphate-15N2,d15 (dilithium)

• UNSPSC Description:

  Deoxythymidine-5'-triphosphate-15N2,d15 (dTTP-15N2,d15) dilithium is deuterium and 15N labeled Deoxythymidine-5'-triphosphate (HY-138615). Deoxythymidine-5'-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5'-triphosphate (dTTP) is used in the synthesis of DNA.

• Target Antigen:

  DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Others

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([15N]1[C@@]2([2H])C([2H])([2H])[C@@](O[2H])([2H])[C@](C([2H])([2H])OP(O[2H])(OP(OP(O[2H])(O[Li])=O)(O[Li])=O)=O)([2H])O2)[15N]([2H])C(C(C([2H])([2H])[2H])=C1[2H])=O

• Molecular Weight:

  511.11

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975;5(2):191-202.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported