Azide-C2-Azide

• Description :

  Azide-C2-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Azide-C2-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

• UNSPSC :

  12352203

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/azide-c2-azide.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [N-]=[N+]=NCCN=[N+]=[N-]

• Molecular Formula :

  C2H4N6

• Molecular Weight :

  112.09

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker

• CAS Number :

  [629-13-0]