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NH-bis (C2-PEG1-azide)

CAT: 0804-HY-140550-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-140550-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NH-bis (C2-PEG1-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH-bis (C2-PEG1-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
2100306-81-6
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nh-bis-c2-peg1-azide.html
Purity
99.87
Solubility
10 mM in DMSO
Smiles
[N-]=[N+]=NCCOCCNCCOCCN=[N+]=[N-]
Molecular Formula
C8H17N7O2
Molecular Weight
243.27
Precautions
H302, H315, H319, H335
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers

Chemical Information

NH-bis(PEG1-azide)
CAS Number2100306-81-6
PubChem CID126961975
IUPAC Name2-(2-azidoethoxy)-N-[2-(2-azidoethoxy)ethyl]ethanamine
Molecular FormulaC8H17N7O2
Molecular Weight243.27
XLogP1.3
Topological Polar Surface Area59.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count12
Heavy Atom Count17
Formal Charge0
Complexity235
SMILES
C(COCCN=[N+]=[N-])NCCOCCN=[N+]=[N-]
InChI
InChI=1S/C8H17N7O2/c9-14-12-3-7-16-5-1-11-2-6-17-8-4-13-15-10/h11H,1-8H2
InChIKey
FXMWPZQWEUFICE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of NH-bis(PEG1-azide)
CAS: 2100306-81-6
CID: 126961975
Formula: C8H17N7O2
MW: 243.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight243.27
XLogP31.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count12
Exact Mass243.14437281
Monoisotopic Mass243.14437281
Topological Polar Surface Area59.2 Ų
Heavy Atom Count17
Formal Charge0
Complexity235
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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