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Atovaquone-d5

CAT: 0804-HY-13832S2-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-13832S2-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Atovaquone-d5 is the deuterium labeled Atovaquone. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome?bc1?complex. Atovaquone is against human and ?P. falciparum?cytochrome?bc1?activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
CAS Number
1329792-63-3
Product Name Alternative
Atavaquone-d5
UNSPSC
12352005
Target
Antibiotic; Cytochrome P450; Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
O=C1C([C@@]2([2H])C([2H])([2H])C[C@H](C3=CC=C(C=C3)Cl)CC2([2H])[2H])=C(C(C4=CC=CC=C41)=O)O
Molecular Formula
C22H14D5ClO3
Molecular Weight
371.87
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5 (177) :177ra37.|[3]Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45 (6) :1771-9.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
Plasmodium

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