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Atovaquone

CAT: 0804-HY-13832-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13832-01Size:5 mg
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Description
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1][2].
CAS Number
95233-18-4
Product Name Alternative
Atavaquone
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Antibiotic; Bacterial; Cytochrome P450; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/atovaquone.html
Purity
99.75
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
O=C1C([C@H]2CC[C@H](C3=CC=C(Cl)C=C3)CC2)=C(O)C(C4=C1C=CC=C4)=O
Molecular Formula
C22H19ClO3
Molecular Weight
366.84
Precautions
H302, H315, H319
References & Citations
[1]Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5 (177) :177ra37.|[2]Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45 (6) :1771-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Plasmodium

Alternative Products

CatalogName
T1491-01Atovaquone

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