J14

• Description :

  J14 is a reversible sulfiredoxin inhibitor with an IC50 of 8.1 μM. J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death[1].

• CAS Number :

  [1043854-13-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/j14.html

• Purity :

  99.91

• Solubility :

  DMSO : ≥ 125 mg/mL

• Smiles :

  O=C(O)C1=CC=C(CSC2=NC(C3=CC=CC=C3)=CC(N4CCN(C5=CC=CC=C5Cl)CC4)=N2)C=C1

• Molecular Formula :

  C28H25ClN4O2S

• Molecular Weight :

  517.04

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kim H, et al. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med. 2016 Feb;91:264-74.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported