4-Epianhydrotetracycline (hydrochloride)

4-Epianhydrotetracycline (hydrochloride)

• CAS Number: 4465-65-0
• UNSPSC Description: 4-Epianhydrotetracycline hydrochloride is a major intermediate product of Tetracycline (HY-A0107). 4-Epianhydrotetracycline hydrochloride shows lethal effects and induces cell apoptosis of zebrafish embryos. 4-Epianhydrotetracycline hydrochloride inhibits Shewanella, E. coli and P. aeruginosa with MIC values of 2, 1 and 64 mg/L, respectively[1].
• Target Antigen: Antibiotic; Apoptosis; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/4-epianhydrotetracycline-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@@](C(C1=C(C2=C3O)O)=O)(C(C(C(N)=O)=C4O)=O)[C@](CC1=C(C2=CC=C3)C)([H])[C@H]4N(C)C.Cl
• Molecular Weight: 462.88
• References & Citations: [1]Wang M, et al. Effects of 4-epianhydrotetracycline on oxidative stress in zebrafish (Danio rerio) embryos. Sci Total Environ. 2021 Nov 20;796:149047.|[2]Wang M, et al. Developmental toxicity and transcriptome analysis of 4-epianhydrotetracycline to zebrafish (Danio rerio) embryos. Sci Total Environ. 2020 Sep 10;734:139227. |[3]Long S, et al. Toxicity of tetracycline and its transformation products to a phosphorus removing Shewanella strain. Chemosphere. 2020 May;246:125681.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported