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DAURK-4 (hydrochloride)

CAT: 0804-HY-137344A-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137344A-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DAURK-4 hydrochloride, an Alisertib derivative, is a potent and selective PROTAC AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects. (Pink: Ligand for target protein (HY-10971) ; Black: Linker (HY-W004640) ; Blue: Ligand for E3 ligase Thalidomide-O-COOH (HY-103597) ).
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/daurk-4-hydrochloride.html
Purity
99.44
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O.Cl
Molecular Formula
C52H53Cl2FN8O12
Molecular Weight
1071.93
References & Citations
[1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A

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