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4-Hydroxypropranolol (hydrochloride)

CAT: 0804-HY-100634-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100634-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroxypropranolol hydrochlorid is an active metabolite of Propranolol. 4-Hydroxypropranolol hydrochlorid is of comparable potency to Propranolol. 4-Hydroxypropranolol hydrochlorid inhibits β1- and β2-adrenergic receptors with pA2 values of 8.24 and 8.26, respectively. 4-Hydroxypropranolol hydrochlorid has intrinsic sympathomimetic activity, membrane stabilizing activity and potent antioxidant properties[1][2][3].
CAS Number
14133-90-5
Product Name Alternative
(±) -4-hydroxy Propranolol (hydrochloride)
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxypropranolol-hydrochloride.html
Purity
99.73
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C2C=CC=CC2=C(OCC(O)CNC(C)C)C=C1.Cl[H]
Molecular Formula
C16H22ClNO3
Molecular Weight
311.80
References & Citations
[1]Fitzgerald JD, et al. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. Br J Pharmacol. 1971 Sep;43 (1) :222-35.|[2]Nelson WL, et al. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. J Med Chem. 1984 Jul;27 (7) :857-61.|[3]Ivan Tong Mak, et al. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2004, 308 (1) :85-90.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

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