Fulvestrant-d5

• Description :

  Fulvestrant-d5 (ICI 182780-d5) is a isotope of Fulvestrant (HY-13636) [1]. Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy.

• Product Name Alternative :

  ICI 182780-d5; ZD 9238-d5; ZM 182780-d5

• UNSPSC :

  12352005

• Hazard Statement :

  H303, H315, H360, H362, H410

• Target :

  Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Others

• Field of Research :

  Others

• Purity :

  99.66

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@]12[C@]([2H])(C([2H])(C[C@]1([C@@]3([C@@H](CC4=C([C@]3(CC2)[H])C=C(C(O)=C4[2H])[2H])CCCCCCCCCS(CCCC(F)(C(F)(F)F)F)=O)[H])[H])[2H])O

• Molecular Formula :

  C32H42D5F5O3S

• Molecular Weight :

  611.80

• Precautions :

  H303, H315, H360, H362, H410

• References & Citations :

  [1]Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991 Aug 1;51 (15) :3867-73.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported