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Fulvestrant

CAT: 0804-HY-13636-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13636-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fulvestrant (ICI 182780) is a pure antiestrogen and a potent estrogen receptor (ER) antagonist with an IC50 of 9.4 nM. Fulvestrant is also a GPR30 agonist. Fulvestrant effectively inhibits the growth of ER-positive MCF-7 cells with an IC50 of 0.29 nM. Fulvestrant also induces autophagy and has antitumor efficacy[1].
CAS Number
129453-61-8
Product Name Alternative
ICI 182780; ZD 9238; ZM 182780
UNSPSC
12352005
Hazard Statement
H303, H315, H360, H362, H410
Target
Apoptosis; Autophagy; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Fulvestrant.html
Purity
99.95
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])[C@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)=O)CC4=C(C=CC(O)=C4)[C@@]3([H])CC2
Molecular Formula
C32H47F5O3S
Molecular Weight
606.77
Precautions
H303, H315, H360, H362, H410
References & Citations
[1]Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991 Aug 1;51 (15) :3867-73.|[2]Osborne CK, et al. Fulvestrant: an oestrogen receptor antagonist with a novel mechanism of action. Br J Cancer. 2004 Mar;90 Suppl 1:S2-6.|[3]Garner F, et al. RAD1901: a novel, orally bioavailable selective estrogen receptor degrader that demonstrates antitumor activity in breast cancer xenograft models. Anticancer Drugs. 2015 Oct;26 (9) :948-56|[4]Yu X, et al.MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy.Mol Cancer. 2015 Dec 15;14:208.|[5]Julia Kuhn, et al. GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat. Eur J Neurosci. 2008 Apr;27 (7) :1700-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
276530-01Fulvestrant

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