DBCO-SS-aldehyde

• Description :

  DBCO-SS-aldehyde is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. DBCO-SS-aldehyde is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• UNSPSC :

  12352203

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  ADC Linker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dbco-ss-aldehyde.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NCCC(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)=O)CCSSCCNC(C4=CC=C(C([H])=O)C=C4)=O

• Molecular Formula :

  C31H29N3O4S2

• Molecular Weight :

  571.71

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Cleavable Linker; Disulfide Cleavable Linker