DBCO-NHCO-PEG2-CH2COOH

• UNSPSC Description:

  DBCO-NHCO-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NHCO-PEG2-CH2COOH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dbco-nhco-peg2-ch2cooh.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(CCOCCOCCC(O)=O)=O

• Molecular Weight:

  464.51

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported