Beclometasone dipropionate (monohydrate)

Beclometasone dipropionate (monohydrate)

• CAS Number: 77011-63-3
• UNSPSC Description: Beclometasone dipropionate monohydrate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma [1][2].
• Target Antigen: Glucocorticoid Receptor; NO Synthase; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;Vitamin D Related/Nuclear Receptor
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/beclometasone-dipropionate-monohydrate.html
• Solubility: 10 mM in DMSO
• Smiles: CCC(OCC([C@@]1([C@@]2([C@@]([C@@]3([H])[C@]([C@H](C2)O)([C@@]4(C(CC3)=CC(C=C4)=O)C)Cl)([H])C[C@@H]1C)C)OC(CC)=O)=O)=O.O
• Molecular Weight: 539.06
• References & Citations: [1]Hrvacić B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75. |[2]Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27.
• Shipping Conditions: Room temperature
• Clinical Information: Launched