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Betamethasone-d5

CAT: 0804-HY-13570SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13570SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Betamethasone-d5 is the deuterium labeled Betamethasone. Betamethasone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive activities. Betamethasone accelerates fetal lung maturation and induces gene expression and apoptosis[1][2][3][4].
UNSPSC
12352211
Target
Apoptosis; Glucocorticoid Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology; Endocrinology; Cancer
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](C[C@H](C)[C@]2(O)C(C([2H])([2H])O)=O)([H])[C@]3([H])CC([2H])([2H])C4=C([2H])C(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C1)=O
Molecular Formula
C22H24D5FO5
Molecular Weight
397.49
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Schwab M, et, al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000 Nov 1;528 (Pt 3) :619-32.|[3]Xie W, et, al. Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci. Winter 2006;36 (1) :39-46.|[4]Kubin ME, et, al. Clinical Efficiency of Topical Calcipotriol/Betamethasone Treatment in Psoriasis Relies on Suppression of the Inflammatory TNFα - IL-23 - IL-17 Axis. Acta Derm Venereol. 2017 Apr 6;97 (4) :449-455.|[5]Hofmann TH, et, al. Various glucocorticoids differ in their ability to induce gene expression, apoptosis and to repress NF-kappaB-dependent transcription. FEBS Lett. 1998 Dec 28;441 (3) :441-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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TMIH-0113-01Betamethasone-d5
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CS-O-14308Betamethasone-d5 21-Phosphate
442639-01Betamethasone-d5 21-Acetate
CS-O-14389Betamethasone-d5 (d4 Major)
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