6-Aminophenanthridine

• Description:

  6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR) . 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301-H319

• Target:

  Prion Protein

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/6-aminophenanthridine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=C2C=CC=CC2=C (C=CC=C3) C3=N1

• Molecular Formula:

  C13H10N2

• Molecular Weight:

  194.23

• Precautions:

  P264-P270-P280-P305+P351+P338-P330-P405-P501

• References & Citations:

  [1]Pang Y, et al. The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition. J Biol Chem. 2013;288 (26) :19081-19089.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  832-68-8