6-Aminophenanthridine

• Description :

  6-Aminophenanthridine inhibits the protein folding activity of the ribosome (PFAR) . 6-Aminophenanthridine competitively occludes the protein substrates from binding to rRNA and thereby inhibits PFAR[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301-H319

• Target :

  Prion Protein

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/6-aminophenanthridine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=C2C=CC=CC2=C(C=CC=C3)C3=N1

• Molecular Formula :

  C13H10N2

• Molecular Weight :

  194.23

• Precautions :

  P264-P270-P280-P305+P351+P338-P330-P405-P501

• References & Citations :

  [1]Pang Y, et al. The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition. J Biol Chem. 2013;288 (26) :19081-19089.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [832-68-8]