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Dot1L-IN-6

CAT: 0804-HY-135129Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-135129Size:1 Each
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Description
Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM[1].
CAS Number
2565705-01-1
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dot1l-in-6.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(N[C@H](C2=NC=CC=C2Cl)C3=C4OC(F)(F)OC4=CC=C3)C(NC5=NC(OC)=NC(OC)=N5)=C1)(C)=O
Molecular Formula
C25H21ClF2N6O6S
Molecular Weight
606.99
References & Citations
[1]Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DOT1L

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