Dot1L-IN-6

• Description:

  Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dot1l-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S (C1=CC=C (N[C@H] (C2=NC=CC=C2Cl) C3=C4OC (F) (F) OC4=CC=C3) C (NC5=NC (OC) =NC (OC) =N5) =C1) (C) =O

• Molecular Formula:

  C25H21ClF2N6O6S

• Molecular Weight:

  606.99

• References & Citations:

  [1]Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  DOT1L

• CAS Number:

  2565705-01-1