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Dot1L-IN-9

CAT: 0804-HY-168083Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168083Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor (IC50: 125 nM) . Dot1L-IN-9 reduces H3K79 dimethylation. Dot1L-IN-9 can be used for anti-leukemia research[1].
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dot1l-in-9.html
Smiles
NC1=C2N=CN(C2=NC=N1)[C@@H]3O[C@H](CN4CCC(CCC5=NC6=CC(C(C)(C)C)=CC=C6N5)CC4)[C@@H](O)[C@H]3O
Molecular Formula
C28H38N8O3
Molecular Weight
534.65
References & Citations
[1]Sethy B, et al. Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents. Bioorg Chem. 2024 Sep 6;153:107771.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DOT1L

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