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4-Desmethoxy Omeprazole

CAT: 0804-HY-135111-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-135111-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
CAS Number
110374-16-8
UNSPSC
12352005
Hazard Statement
H302, H315, H402, H411
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/4-desmethoxy-omeprazole.html
Purity
98.99
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC=C2N=C(S(CC3=NC=C(C)C=C3C)=O)NC2=C1
Molecular Formula
C16H17N3O2S
Molecular Weight
315.39
Precautions
H302, H315, H402, H411
References & Citations
[1]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32 (8) :821-7.|[2]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37 (1) :145-50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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