Omeprazole-d3

Omeprazole-d3

• CAS Number: 922731-01-9
• UNSPSC Description: Omeprazole-d3 is deuterium labeled Omeprazole. Omeprazole, a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].
• Target Antigen: Autophagy; Bacterial; Proton Pump
• Type: Isotope-Labeled Compounds
• Related Pathways: Anti-infection;Autophagy;Membrane Transporter/Ion Channel
• Field of Research: Cancer; Infection; Metabolic Disease
• Purity: 98.99
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: CC(C(OC)=C(C)C=N1)=C1CS(C2=NC3=CC=C(OC([2H])([2H])[2H])C=C3N2)=O
• Molecular Weight: 348.43
• References & Citations: [1]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.|[2]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported