PNP-ADPr

• Description :

  PNP-ADPr is a colorimetric substrate that used for the first continuous Poly (ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr can be used for the research of poly (ADP-ribose) polymerase (PARP) enzymes[1][2].

• Product Name Alternative :

  ADP-ribose-pNP

• UNSPSC :

  12352005

• Target :

  Poly (ADP-ribose) Glycohydrolase (PARG)

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/pnp-adpr.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](OC5=CC=C([N+]([O-])=O)C=C5)O4)(O)=O)(O)=O

• Molecular Formula :

  C21H26N6O16P2

• Molecular Weight :

  680.41

• References & Citations :

  [1]Drown BS, et al. Monitoring Poly (ADP-ribosyl) glycohydrolase Activity with a Continuous Fluorescent Substrate. Cell Chem Biol. 2018;25 (12) :1562-1570.e19.|[2]Nottbohm AC, et al. A colorimetric substrate for poly (ADP-ribose) polymerase-1, VPARP, and tankyrase-1. Angew Chem Int Ed Engl. 2007;46 (12) :2066-2069.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [939028-75-8]