PNP-ADPr

CAT: 0804-HY-134354Size: 1 EachDry Ice: NoHazardous: No

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Description

PNP-ADPr is a colorimetric substrate that used for the first continuous Poly (ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr can be used for the research of poly (ADP-ribose) polymerase (PARP) enzymes[1][2].

CAS Number

939028-75-8

Product Name Alternative

ADP-ribose-pNP

UNSPSC

12352005

Target

Poly (ADP-ribose) Glycohydrolase (PARG)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pnp-adpr.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H](OC5=CC=C([N+]([O-])=O)C=C5)O4)(O)=O)(O)=O

Molecular Formula

C21H26N6O16P2

Molecular Weight

680.41

References & Citations

[1]Drown BS, et al. Monitoring Poly (ADP-ribosyl) glycohydrolase Activity with a Continuous Fluorescent Substrate. Cell Chem Biol. 2018;25 (12) :1562-1570.e19.|[2]Nottbohm AC, et al. A colorimetric substrate for poly (ADP-ribose) polymerase-1, VPARP, and tankyrase-1. Angew Chem Int Ed Engl. 2007;46 (12) :2066-2069.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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