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8-Nitroguanosine

CAT: 0804-HY-134315-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-134315-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
8-Nitroguanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].
CAS Number
337536-53-5
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/8-nitroguanosine.html
Purity
95.52
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N(C([N+]([O-])=O)=N2)C3=C2C(NC(N)=N3)=O)O[C@@H]1CO
Molecular Formula
C10H12N6O7
Molecular Weight
328.24
References & Citations
[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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